Transhumanity stands on the edge of evolution and extinction. With the ability to upload our minds and nanofabricate almost anything, death and scarcity were nearly defeated. Then a war against super-intelligent AIs infected with an alien virus wiped out 95% of the population. Earth is a ruined wasteland, overrun by machines. The remnants of transhumanity—bio-engineered humans, uplifted animals, and infolife—expanded throughout the Solar System.
It's one of those months where there's so much to do and learn that you feel like you need to be in than one place at the same time. That's no problem! Upload your mindstate, fork it into copies each for its own chore, use standard tools to clip away their unnecessary memories and cut down that file size, and transmit them far afield - and when they come home, merge yourself together again. Nothing to worry about, perfectly routine.
But today you're back at home on Mars, along with your other forks - and your original self's gone missing. That's bad.
(This is a published scenario for Eclipse Phase, a game of transhumanism and horror)